Niccolò Acciaioli or Acciaiuoli (1310 – 8 November 1365) was an Italian noble, a member of the Florentine banking family of the Acciaioli. He was the grand seneschal of the Kingdom of Naples and count of Melfi, Malta, and Gozo in the mid-fourteenth century. He was the son of Acciaiolo, a wealthy Florentine merchant. He had a sister by the name of Andrea Acciaioli.
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